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全球共有数百万的妇女患有不同程度的子宫内膜异位症(EMs),每15例育龄妇女中就有1例患有该病,其中25％伴有不育,80％有月经失调。瘦素(leptin)是人类肥胖基因的产物,在肥胖个体中明显升高。目前认为血浆中的leptin浓度与雄激素和促性腺激素有关。丹那唑是治疗EMs的常用药物,80年代末以来GnRH-a广泛应用于绝经前的EMs。以上两种药物是否会影响血浆中的leptin浓度是本研究的目的。 研究对象为20例不育妇女,年龄18～42岁,有规则月
Millions of women worldwide have varying degrees of endometriosis (EMs), one out of every 15 women of reproductive age, 25% with infertility and 80% with menstrual disorders . Leptin, a product of the human obesity gene, is markedly elevated in obese individuals. At present, the concentration of leptin in plasma is related to androgen and gonadotropin. Danazol is a commonly used drug for the treatment of EMs. GnRH-a has been widely used in premenopausal EMs since the late 1980s. Whether these two drugs affect the concentration of leptin in plasma is the purpose of this study. Subjects for the 20 cases of infertile women, aged 18 to 42 years, there are regular months