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目的 探讨 ｎｍ ２３、组织蛋白酶 Ｄ（ Ｃａｔｈ Ｄ）蛋白表达在乳腺癌预后及转移中的价值。方法 应用免疫组织化学方法，观察随访 ３ 年以上的 ５２ 例乳腺癌组织中 ｎｍ ２３ 和 Ｃａｔｈ Ｄ 蛋白的表达。结果 癌组织 ｎｍ ２３ 高表达２４ 例（４６２％ ）， Ｃａｔｈ Ｄ 阳性 ３０ 例（５７７％ ）。ｎｍ ２３ 的表达与淋巴结转移及预后相关（ Ｐ ＜ ０．０１； Ｐ ＜ ０．０５ ）； Ｃａｔｈ Ｄ 的表达与预后相关（ Ｐ ＜ ０．０５）；ｎｍ ２３ 的表达与 Ｃａｔｈ Ｄ的表达呈负相关（ Ｐ ＜ ０．０１）。结论 ｎｍ ２３ 与 Ｃａｔｈ Ｄ 蛋白表达可作为判断乳腺癌患者预后的一个重要参考指标
Objective To investigate the value of nm23 and Cath-D protein expression in the prognosis and metastasis of breast cancer. Methods Immunohistochemistry was used to observe the expression of nm23 and CathD protein in 52 cases of breast cancer that were followed for more than 3 years. Results There were 24 cases (46. 2%) of high expression of nm23 in cancer tissues and 30 cases of Cath-D (57.7%). The expression of nm23 was correlated with lymph node metastasis and prognosis (P < 0.01; P <0.05); Cath D expression was associated with prognosis (P <0.05); nm23 expression and Cath D expression Negative correlation (P < 0.01). Conclusion The expression of nm23 and CathD protein can be used as an important reference to predict the prognosis of breast cancer patients.