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甲氟喹是喹啉甲醇类抗疟药,单次剂量治疗时对各种种属的人疟原虫感染都有效,包括对于多种有抗药性的恶性疟原虫,可用于预防或治疗。甲氟喹可用其盐酸盐的单方,或使用与磺胺多辛及乙胺嘧啶的复合制剂。药物无非肠道给药的剂型。在健康自愿者中甲氟喹的吸收半衰期为1～4h,达峰时间7～12h(中位数10.7),平均峰浓度50～110ng·ml~(1-)(中位数83),全身表观分布容积(Vd/f)为13.3～40.9 L/kg(中位数19.2),全身清除率(CL/f0.022～0.072 L·h~(-1)·kg~(-1)(中位数0.026),末端相消除半衰期13.8～40.9天(中
Mefloquine is a quinolinemethanol-based anti-malaria drug that is effective against Plasmodium falciparum infections of all species in a single dose, including multiple resistant P. falciparums for prophylaxis or treatment. Mefloquine can be used in its unilateral hydrochloride, or with sulfadoxine and pyrimethamine combination of preparations. No parenteral drug delivery form. The half-life of mequindox in healthy volunteers was 1 ~ 4h, the peak time was 7 ~ 12h (median 10.7), the average peak concentration was 50 ~ 110ng · ml ~ (-1) (median 83) The apparent volume of distribution (Vd / f) was 13.3-40.9 L / kg (median 19.2), and the systemic clearance rate (CL / f 0.022-0.072 L · h -1 · kg -1 Median 0.026), the elimination phase half-life of 13.8 ~ 40.9 days (in