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阿司匹林偶尔应用无严重副反应,但用于老年患者长期抗炎治疗时,则可能发生副反应。阿司匹林口服迅速吸收,t_(1/2)为15min,在血和肝中去乙酰生成水杨酸盐,后者80％～90％与血浆蛋白结合。在肝中主要转变为甘氨酸结合物(75％)。血中水杨酸盐浓度主要影响因素为:(1)尿 pH<6时,呈非解离状态,易发生逆向扩散透过肾小管,碱性尿时,其清除率增加;(2)肝中甘氨酸结合酶的浓度,水杨酸盐达60mg/L 时,结合酶能力即饱和,此时 t_(1/2)为2～3h,抗炎剂量和中毒剂量时分别可达12,15～30h。
Occasional application of aspirin without serious side effects, but for the elderly patients with long-term anti-inflammatory treatment, the side effects may occur. Aspirin rapidly absorbed orally, t_ (1/2) for 15min, in the blood and liver to acetyl salicylate, the latter 80% to 90% of the plasma protein binding. The main conversion in the liver to glycine conjugates (75%). The main influencing factors of salicylate concentration in blood are as follows: (1) When the urine pH is less than 6, it is non-dissociated and prone to reverse diffusion through the renal tubules and alkaline urine, the clearance rate increases; (2) The concentration of glycine-binding enzyme, salicylate up to 60mg / L, the capacity of the enzyme that is saturated, then t_ (1/2) for 2 ~ 3h, anti-inflammatory dose and poisoning dose up to 12,15 ~ 30h.