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急性髓性白血病HB-1细胞系是由辐射处理的CBA/N小鼠脾脏细胞克隆并建立起来的。静脉注射HB-1细胞到正常CBA/N小鼠体内会诱发急性髓性白血病综合症,并使小鼠2周左右死亡。一般情况下,白血病细胞被接种到小鼠后会侵入造血器官、肺、肾和肝脏。我们在研究中发现了一令人感兴趣的现象,不仅在小鼠的肺、肾和肝脏中,而且在大脑和小脑中也观察到了HB-1细胞。白血病细胞能穿过血脑屏障在正常情况下是难以理解的,因为血脑屏障可阻止血细胞进入脑内,并且严格有选择地让小分子通过。因此,HB-1细胞将是阐明形成血脑屏障的内皮细胞上的附贴分子和选择性地让特殊细胞侵入脑的一个很好的模型。
The acute myeloid leukemia HB-1 cell line was cloned and established from irradiated CBA / N mouse spleen cells. Intravenous injection of HB-1 cells into normal CBA / N mice induces acute myeloid leukemia syndrome and causes the mice to die about two weeks later. In general, leukemia cells invade blood-forming organs, lungs, kidneys and liver after being inoculated into mice. We found an interesting phenomenon in our study that HB-1 cells were observed not only in the lung, kidney and liver of mice, but also in the brain and cerebellum. Leukemia cells can cross the blood-brain barrier under normal circumstances is difficult to understand, because the blood-brain barrier can prevent blood cells into the brain, and strictly through the small molecules. Therefore, HB-1 cells will be a good model to elucidate the attachment of molecules on the endothelial cells that form the blood-brain barrier and to selectively allow specific cells to invade the brain.