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目的观察α-干扰素治疗乙型肝炎相关性肾炎的临床疗效。方法符合乙型肝炎相关性肾炎诊断标准的36例患者,随机分为两组,对照组18例给予保肝、降酶、对症常规治疗,治疗组18例在对照组治疗的基础上皮下注射α-干扰素抗病毒治疗,观察两组患者治疗前后肝肾功能、乙型肝炎系列各项指标、HBV-DNA滴度、尿蛋白、尿红细胞的变化。结果治疗组在促进HBV血清标志物变化、降低HBV-DNA水平、改善肝肾功能方面明显优于对照组。结论α-干扰素治疗乙肝相关性肾炎疗效明确。
Objective To observe the clinical efficacy of α-interferon in the treatment of hepatitis B-related nephritis. Methods Thirty-six patients who met the diagnostic criteria of hepatitis B-related nephritis were randomly divided into two groups. The control group received 18 cases of liver protection, enzyme-lowering and symptomatic treatment. 18 cases in the treatment group were injected subcutaneously with α - Interferon antiviral therapy, liver and kidney function before and after treatment, hepatitis B series of indicators, HBV-DNA titer, urinary protein, urinary erythrocyte changes were observed. Results The treatment group was significantly better than the control group in promoting the changes of serum HBV markers, reducing the level of HBV-DNA and improving the liver and kidney function. Conclusion α-interferon treatment of hepatitis B-related nephritis clear effect.