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目的探讨滋养细胞肿瘤患者子宫病灶大小与化疗疗程的关系。方法应用彩色多普勒超声诊断仪探测了滋养细胞肿瘤２９例子宫病灶的大小、子宫血流情况，并与治愈时化疗疗程数作比较。结果随着子宫上病灶的增大，子宫动脉的搏动指数（ＰＩ）及阻力指数（ＲＩ）逐渐下降，病灶周围血流的搏动指数及阻力指数也逐渐下降，而治愈所需的疗程数逐渐增加，表明子宫病灶的大小、子宫血流情况与化疗效程之间有一定关联，而血清β－ｈＣＧ水平不能反映子宫病灶的大小及病情的严重程度。结论应用彩超测定子宫病灶及血流情况有助于估计滋养细胞肿瘤患者的预后，而β－ｈＣＧ水平与病情严重程度、预后不平行。
Objective To investigate the relationship between the size of uterine lesions and the course of chemotherapy in patients with trophoblastic tumor. Methods The size of uterine lesions and uterine blood flow in 29 cases of trophoblastic tumor were detected by color Doppler sonography and compared with the number of chemotherapy courses when cured. Results With the increase of uterine lesions, the pulsatility index (PI) and resistance index (RI) of uterine artery gradually decreased. The pulsatility index and resistance index of peripheral blood flow of the uterus decreased gradually, while the number of courses of treatment required for curing increased gradually , Indicating that the size of the uterine lesions, uterine blood flow and the relationship between the efficacy of chemotherapy has a certain relationship, and serum β-hCG levels can not reflect the size of the uterine lesions and the severity of the disease. Conclusion The determination of uterine lesions and blood flow by color Doppler ultrasound is helpful to estimate the prognosis of patients with trophoblastic tumor. However, the level of β-hCG is not parallel with the severity and prognosis.