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L-色氨酸常用于治疗失眠、各种神经精神障碍和局部肌筋膜疼痛综合征.一般认为它无明显毒性.但作者近年来发现该药能引起一种嗜伊红细胞增多—肌痛综合征.本文报告25例该综合征的临床病理和实验室研究结果.25例中,男8例,女17例.年龄26～74岁.患者多因失眠或焦虑而自行服用该制剂,每日剂量1～6g(平均1.9g),用药1～30月(平均11.7月).最常见的临床表现是肌痛(100%),常伴肌痉挛、感觉过敏(64%)和感觉异常(64%).多有疲乏无力,可出现发热(40%)、体重减轻(64%)、肌肉触痛(56%)和对称性多关节痛(44%),偶伴滑膜炎.经临床或神经电生理检查(肌电图和神经传导速度测定)证实为肌病和神经病者,分别占64%和36%.近端型肌病比远端型多见.神经病以感觉障
L-tryptophan commonly used in the treatment of insomnia, a variety of neuropsychiatric disorders and local myofascial pain syndrome is generally believed that it has no obvious toxicity, but in recent years the authors found that the drug can cause a combination of eosinophilia - myalgia This article reports 25 cases of the clinical and pathological findings of the syndrome and laboratory findings in 25 cases, 8 males and 17 females, aged 26 to 74. Patients were mostly due to insomnia or insomnia to take the preparation, daily Dosage 1 ~ 6g (average 1.9g), medication for 1 ~ 30 months (mean 11.7 months) .The most common clinical manifestations are muscle pain (100%), often accompanied by muscle spasms, hyperesthesia (64%) and sensory abnormalities (40%), weight loss (64%), muscle tenderness (56%) and symmetrical polyarticular pain (44%), even with synovitis. The clinical or Neuromuscular examination (electromyography and nerve conduction velocity measurement) proved to be myopathy and neuropathy, accounting for 64% and 36%, respectively, and proximal myopathy was more common than distal type.