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目的:探讨肺功能检测在儿童哮喘长期管理中的应用价值。方法:采用德国耶格肺功能仪对该院2010年3月~2012年12月期间纳入管理的463例哮喘儿童定期进行肺通气功能检测,并将测得的结果用于调整治疗方案。结果:463例哮喘儿童的初始肺通气功能可有不同程度的损害:其中对呼吸道阻力影响较大的小气道肺功能参数,包括用力呼气50%流量(FEF50)、75%流量(FEF75)、25%~75%平均流量(MMEF)的异常率均≥78.6%;用力呼气25%流量(FEF25)和大气道肺功能参数的异常率较小,均≤30.7%。第3、6、10个月定期复查并调整治疗方案,第15个月测得最终肺通气功能:小气道肺功能参数异常率与初始比较明显改善,P<0.01,有统计学差异;FEF25和大气道肺功能参数异常率与初始比较,P>0.05,无统计学差异。结论:小气道肺功能检测不仅能客观反应哮喘儿童肺功能损害的存在与否和程度,更能为哮喘儿童长期管理治疗、疗效的判定提供可靠依据,值得临床推广应用。
Objective: To investigate the value of pulmonary function test in long-term management of childhood asthma. Methods: A total of 463 asthmatic children with asthma admitted from March 2010 to December 2012 in the hospital were tested for pulmonary ventilation by the German Yagelospirometer. The measured results were used to adjust the treatment regimen. Results: The initial lung ventilation of 463 asthmatic children may have different degrees of damage: Among them, small pulmonary function parameters, including FEF50, FEF75, The abnormal rate of 25% -75% average flow (MMEF) was ≥78.6%. The abnormal rate of pulmonary function parameter of forced expiratory 25% flow (FEF25) and airway was less than 30.7%. On the 3rd, 6th, and 10th months, the regimen was regularly reviewed and adjusted. The final pulmonary ventilation function was measured at the 15th month: the abnormal rate of pulmonary function parameters of small airway was significantly improved compared with the initial, P <0.01, with statistical difference; FEF25 and Airway pulmonary function parameters abnormalities and initial comparison, P> 0.05, no statistical difference. Conclusion: The detection of small airway lung function can not only objectively reflect the existence and extent of lung dysfunction in children with asthma, but also provide a reliable basis for the long-term management and treatment of asthma children. It is worthy of clinical application.