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目的:分析平罗地区儿童社区获得性肺炎(CAP)住院病例中肺炎链球菌(SP)感染的耐药状况,为合理使用抗生素提供依据。方法:对2007年1月~2010年12月因CAP住院的4 780例患儿进行痰培养,选择典型菌落用传统方法进行SP的鉴定,分离出SP 344株,用纸片扩散法(K-B法)进行药敏试验,并用稀释法作补充。结果:344株SP对青霉素不敏感率为45.6%,2007~2008年时间段SP对青霉素、红霉素、克林霉素、头孢噻肟、头孢曲松、氧氟沙星的耐药率分别为38.5%、38.3%、4.8%、16.0%、16.4%、3.6%;2009~2010年时间段SP对上述药物的耐药率分别为60.9%、68.0%、42.6%、36.7%、32.3%、3.1%;2007~2010年SP对万古霉素均100%的敏感,青霉素不敏感肺炎链球菌(PNSSP)对红霉素、克林霉素、头孢噻肟、头孢曲松、氧氟沙星的耐药率均高于青霉素敏感肺炎链球菌(PSSP)。结论:CAP的SP对万古霉素、氧氟沙星的敏感性极高,对青霉素、红霉素、克林霉素、头孢噻肟、头孢曲松的耐药率出现逐年增加的趋势,PNSSP呈现多重耐药性。
OBJECTIVE: To analyze the drug resistance of S. pneumoniae (SP) in hospitalized children with community-acquired pneumonia (CAP) in Pingluo district and provide the basis for rational use of antibiotics. Methods: From January 2007 to December 2010, 4780 children admitted to CAP for sputum culture were selected for sputum culture. Typical colonies were selected for SP identification by traditional methods. SP 344 strains were isolated and spread by disk diffusion method (KB method ) For susceptibility testing and supplement with dilution method. Results: The insensitivity rate of 344 strains to penicillin was 45.6%. The resistance rates of SP to penicillin, erythromycin, clindamycin, cefotaxime, ceftriaxone and ofloxacin during 2007-2008 were respectively Were 38.5%, 38.3%, 4.8%, 16.0%, 16.4% and 3.6% respectively. The resistance rates of SP to these drugs from 2009 to 2010 were 60.9%, 68.0%, 42.6%, 36.7% and 32.3% 3.1%; 2007 to 2010 SP to vancomycin are 100% sensitive to penicillin-insensitive Streptococcus pneumoniae (PNSSP) to erythromycin, clindamycin, cefotaxime, ceftriaxone, ofloxacin Resistance rates were higher than penicillin-sensitive Streptococcus pneumoniae (PSSP). CONCLUSIONS: The SP of CAP is highly susceptible to vancomycin and ofloxacin. The resistance rates to penicillin, erythromycin, clindamycin, cefotaxime and ceftriaxone increase year by year. PNSSP Show multiple drug resistance.