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目的 :检测survivin、ki6 7、cyclinB1在宫颈癌中的表达 ,探讨它们与宫颈癌组织增殖、细胞周期与凋亡的关系。方法 :应用免疫组化SABC、SP法。结果 :(1)宫颈癌中survivin、ki6 7、cyclinB1表达显著高于正常宫颈组织 (P <0 .0 1) ;(2 )survivin表达与年龄、临床分期和淋巴结转移有关 ,但与宫颈癌组织细胞类型及分化程度无明显相关性。ki6 7表达只与临床分期有关 ,与年龄、组织细胞类型、淋巴结转移及分化程度无明显相关关系。cyclinB1表达与临床病理特征之间无明显相关性 ;(3)宫颈癌组织中survivin表达与ki6 7、cyclinB1表达显著相关。结论 :survivin、ki6 7、cyclinB1异常表达与宫颈癌显著相关 ,宫颈癌的发生与凋亡抑制和增殖能力增强有关。
OBJECTIVE: To detect the expression of survivin, ki6 7 and cyclinB1 in cervical cancer, and to explore their relationship with the proliferation, cell cycle and apoptosis of cervical cancer. Methods: Immunohistochemical SABC, SP method. Results: (1) The expression of survivin, ki6 7 and cyclinB1 in cervical cancer was significantly higher than that in normal cervical tissue (P <0.01). (2) The expression of survivin was related to age, clinical stage and lymph node metastasis, There was no significant correlation between cell type and differentiation. The expression of ki6 7 only correlated with clinical stage, but not with age, cell type, lymph node metastasis and differentiation degree. There was no significant correlation between the expression of cyclinB1 and clinicopathological features. (3) The expression of survivin in cervical cancer was significantly correlated with the expression of cyclinB1 and ki67. Conclusion: The abnormal expressions of survivin, ki6 7 and cyclinB1 are significantly associated with cervical cancer. The occurrence of cervical cancer is related to the inhibition of apoptosis and the enhancement of proliferative capacity.