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以前认为活化型维生素D_3〔1α,-二羟维生素D_3,1.25-(OH)_2-D_3〕参与钙盐代谢调节;近年发现,它也有免疫调节功能,如人类B及T细胞受致分裂原或抗原刺激后可表达出1,25-(OH)_2-D_3特异受体,它对受刺激的人外周血单个核细胞(PBMC)也有抗增殖作用,或许此作用与激素抑制Ig产生的原因有关;最近又发现,1,25-(OH)_2-D_3能抑制PHA刺激PBMC产生白细胞介素2(IL_2).但上述实验并未阐明
In the past, it was thought that activated vitamin D_3 [1α, -dihydroxyvitamin D_3,1.25- (OH) _2-D_3] is involved in the regulation of calcium metabolism. In recent years, it has also been found to have immunomodulatory functions such as human B and T cells undergoing mitogen or Antigen stimulation can express 1,25- (OH) _2-D_3 specific receptor, which has antiproliferative effect on stimulated human peripheral blood mononuclear cells (PBMCs), which may be related to the reason that hormone inhibits Ig production Recently, it was also found that 1,25- (OH) _2-D_3 can inhibit the production of interleukin 2 (IL_2) by PBMC stimulated by PHA. However, the above experiment did not clarify