广东省异常血红蛋白研究——Ⅲ、Hb—广州[α64(E13)ASP→Gly]的结构分析

• 作 者: 刘誉 任邦哲
• 机 构: 暨南大学医学院生化教研室,暨南大学医学院生化教研室,
• 出 处: 暨南理医学报(医学专版)
• 发表日期: 1986年02期
• 关键词: E13)ASP Gly Hb 异常血红蛋白 指纹 顺序测定 结构分析 先证者 α链 指纹图谱分析

本文报导1983年9月在暨南大学新生中进行异常Hb普查时,用醋酸纤维薄膜电泳发现一种α链异常的慢泳血红蛋白突变体。先证者男性,汉族,21岁,异常Hb含量为22.2％,血浓学检查显示轻度贫血。经用指纹图谱分析及氨基酸定量与顺序测定,其结果证明α链第64位门冬氨酸被甘氨酸取代。这是一种文献中尚未曾报导过的Hb新变种,根据习惯,按发现地点命名为“Hb—广州”[Guangzhou α84(E13)ASP→Gly]。

This article reports an abnormal Hb census of freshmen in Jinan University in September 1983 when a hemolymph variant with a-chain abnormality was detected by a cellulose acetate membrane electrophoresis. Probability of male, Han, 21 years old, abnormal Hb content was 22.2%, blood concentration examination showed mild anemia. Fingerprinting and amino acid quantification and sequencing were used to prove that aspartic acid at position 64 of the α-chain was substituted by glycine. This is a new variant of Hb that has not been reported in the literature. According to the habit, it was named “Guangzhou α84 (E13) ASP → Gly” according to the site of the discovery.