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心房颤动是临床上最常见的心律失常之一,血栓栓塞并发症是其致残、致死的主要原因。经食管超声检查发现,非瓣膜性房颤患者心房内血栓90%位于左心耳。因此,预防左心耳血栓形成可能会减少血栓栓塞事件的发生。口服抗凝药是预防房颤血栓栓塞并发症的有效方法,但是很多患者不能耐受口服抗凝药药物治疗。随着心血管介入治疗和器械研发的进展,经皮左心耳封堵预防卒中越来越受到关注,已经成为一种替代华法林预防房颤并发卒中的有效方法。
Atrial fibrillation is one of the most common cardiac arrhythmias in clinical practice. Thromboembolic complications are the main cause of disability and death. Trans-esophageal ultrasound examination found that non-valvular atrial fibrillation in patients with atrial thrombus 90% in the left atrial appendage. Therefore, the prevention of left atrial appendage thrombosis may reduce the incidence of thromboembolic events. Oral anticoagulation is an effective method to prevent the complications of atrial fibrillation thromboembolism, but many patients can not tolerate oral anticoagulant drug treatment. With the progress of cardiovascular interventional therapy and device development, percutaneous left atrial appendage occlusion prevention is becoming more and more concerned. It has become an effective alternative to warfarin in preventing stroke complicated by atrial fibrillation.