【摘 要】
：
DNA digital storage provides an alternative for information storage with high density and long-term stability.Here,we report the de novo design and synthesis of
【机 构】
：
School of Microelectronics,Tianjin University,Tianjin 300072, China;Frontier Science Center for Synt
论文部分内容阅读
DNA digital storage provides an alternative for information storage with high density and long-term stability.Here,we report the de novo design and synthesis of an artificial chromosome that encodes two pictures and a video clip.The encoding paradigm utilizing the superposition ofsparsified error correction codewords and pseudo-random sequences tolerates base insertions/deletions and is well suited to error-prone nanopore sequencing for data retrieval.The entire 254 kb sequence was 95.27％ occupied by encoded data.The Transformation-Associated Recombination method was used in the construction of this chromosome from DNA fragments and necessary autonomous replication sequences.The stability was demonstrated by transmitting the data-carrying chromosome to the 100th generation.This study demonstrates a data storage method using encoded artificial chromosomes via in vivo assembly for write-once and stable replication for multiple retrievals,similar to a compact disc,with potential in economically massive data distribution.
其他文献
人体解剖是医学院校基础医学教育的重要组成部分,运用翻转课堂教学模式和生命科学馆中的丰富馆藏提高解剖教学质量和思政教育水平,更好地适应现代教育的要求。
目的探讨结构化问诊联合思维导图在《健康评估》护理问诊见习教学中的应用效果。方法采用整群抽样随机对照的方法,以入科见习组次为单位,选取广西医科大学护理学院2018级高职护理专业学生253名作为研究对象,采用随机数字表法进行分组,对照组126名采用传统教学法,实验组127名采用结构化问诊联合思维导图的教学方法,两组护生均进行真实的问诊实践,并比较两组护生的问诊时间、整理问诊资料所需时间、病历书写的完整性以及教学满意度情况。结果两组护生在问诊时间、整理问诊资料所需时间、病历书写的完整性以及教学满意度比较,实验组
种子萌发是植物早期生活史中最重要的阶段,决定了植物的生态位和地理分布范围,对外来植物的入侵潜力有重要影响.盐沼植物互花米草(Spartina alterniflora)在中国沿海滩涂的入
Like nanomaterials,bacteria have been unknowingly used for centuries.They hold significant economic potential for fuel and medicinal compound production.Their f
The COVID-19 pandemic has killed more than 1 000 000people within nine months in 2020.The world is changed as the cities were locked down,the traffic reduced,an
由于疫情影响,留学生无法返回国内参加实地面授学习,而传统的线下教学模式已无法达到身处境外留学生的教学要求。随着我国科技与网络技术的高速发展,“互联网+教育”教学模式已在国内迅速普及,在线课堂打破传统课堂的空间限制,综合多种手段进行线上教学,使学生能够灵活地掌握学习时间。“互联网+教育”教学模式的特点为解决留学生疫情期间的学习困境,寻找到了突破口。
目的探讨叙事性教学法在血液学科护理实习生临床实践及护理教学中的应用效果。方法选择2018年7月~2019年7月我院血液科护理实习生为研究对象,将70名实习护生按实习单双批次依据进行分组,单批次的35名护生分为对照组,采用常规教学方法;双批次的35名护生分为实验组,采用叙事性教学法。比较两组护生出科考核成绩和教学质量反馈,以及患者对护生的满意度评价得分情况。结果实验组护生各项考核成绩均显著优于对照组(P<0.05);患者对护生的满意度评价比较,实验组护生的满意度评价得分高于对照组(P<0.05)
We report a new Cretaceous multituberculate mammal with 3D auditory bones preserved.Along with other fossil and extant mammals,the unequivocal auditory bones di
The oxygenation of Earth's atmosphere is widely regarded to have played an important role in early-life evolution.Chromium(Cr)isotopes recorded in sedimentary r
Natural biological systems are constantly developing efficient mechanisms to counter adverse effects of increasing human population and depleting energy resourc