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目的探讨异种(猪)皮作为微粒皮移植覆盖物的可行性。方法选择10例深度大面积烧伤患者,于患者行切痂植皮术前1 d,将1只50 kg左右的纯白猪处死后清洗、剃毛、消毒,切取2张含少量脂肪的皮片,用鼓式取皮机反取成全厚或中厚皮。先播散自体微粒皮,再将猪皮打孔覆盖其上加压包扎。观察患者术后猪皮排异、微粒皮成活情况,以及创面愈合时间和术后1年患者的功能恢复情况。结果术后2周猪皮完整、与创面粘贴好;术后4～5周猪皮呈干痂状,逐渐与微粒皮分离,微粒皮已生长融合,创面基本愈合;术后6～8周猪皮全部脱落,创面愈合。10例患者创面愈合时间为42～56 d[(50±5)d]。术后1年见患者术区虽有表浅瘢痕,但其弹性和功能均恢复正常。结论用猪皮替代同种异体皮覆盖自体微粒皮修复深度烧伤创面可行。
Objective To investigate the feasibility of xenobium (pig) skin as a covering for skin graft. Methods Ten patients with deep and large area burn were selected. One day before eschar excision and skin grafting, a white pig weighing about 50 kg was sacrificed and washed, shaved and disinfected. Two small fat-containing skin pieces were cut with Drum take-off machine into full thickness or thick skin. The first sowing self-particle skin, and then the pigskin punch covering the pressure bandage. Postoperative pig skin excision and microsurgery were observed, as well as wound healing time and functional recovery of patients after 1 year. Results The pigs were intact 2 weeks after operation and glued well with the wounds. The pigs were dry scabs 4 to 5 weeks after operation and gradually separated from the microspheres. The microscopic skin had been fused and the wound surface healed basically. After 6 to 8 weeks Skin all off, wound healing. The wound healing time was 10 days in 42 to 56 days [(50 ± 5) days]. Although there was a superficial scar in one year after operation, its elasticity and function returned to normal. Conclusion pig skin instead of allogenic skin covered autologous skin repair deep burn wounds feasible.