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耳垂皱褶(Ear Lobe Crease)与冠心病的关系于1973年由Fronk首先提出冠心病可发生此征,称为阳性耳垂征(Poss-tiveearlobe Sign)。1974年Lschstein等证明在急性心肌梗塞病人有许多出现耳垂皱褶征,并认为此体征可提示冠心病的存在。相继欧美临床学家通过临床诊断,冠状动脉造影,尸检进一步查明此征与冠状动脉疾病密切相关。1982年村井淳志等也证明此征在动脉硬
Ear Lobe Crease (Ear Lobe Crease) and coronary heart disease in 1973 by Fronk first proposed coronary heart disease can occur this sign, known as the positive ear lobe sign (Poss-tiveearlobe Sign). In 1974, Lschstein et al. Demonstrated that many of the patients with acute myocardial infarction had lobular pleat folds and thought this sign could indicate the presence of coronary heart disease. Clinicians in Europe and America have passed the clinical diagnosis, coronary angiography, autopsy to further identify this sign and coronary artery disease are closely related. Tsuji Murai 1982 also proved that this sign in the arterial stiffness