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自1965年Gold等发现癌胚抗原(下称CEA)以来,血浆CEA的测定在临床上被广泛用于诊断癌肿、预测癌肿的复发和转移、评价化疗和手术的疗效。近年来还广泛研究消化液中CEA的测定,但认为消化液中存在较多的能和CEA呈交叉反应的非特异性抗原(下称NCA),而且胃液中的酸和胃蛋白酶能影响CEA值。为此,作者用Zeege】法放射免疫测定(下称RIA)和Sand-wich法RIA,比较胃癌、胃演疡和慢性胃炎者胃液CEA值,对比研究四肤胃泌素(下称TG)刺激前后此值和胃液酸度、胃蛋白酶活性的关系,以娜讨胃液CEA值测定的临床意丸本文收集经X线和
Since the discovery of Carcinoembryonic Antigen (CEA) by Gold et al. in 1965, the measurement of plasma CEA has been widely used clinically to diagnose cancer, predict cancer recurrence and metastasis, and evaluate the efficacy of chemotherapy and surgery. In recent years, the determination of CEA in digestive juices has been widely studied, but it is believed that there are many non-specific antigens (hereinafter referred to as NCA) that can cross-react with CEA, and the acid and pepsin in gastric juice can affect the CEA value. To this end, the author used Zeege’s radioimmunoassay (hereinafter referred to as RIA) and Sand-wich RIA to compare CEA values of gastric juices in patients with gastric cancer, gastric ulcers, and chronic gastritis, and compared the gastrin-stimulating hormone (TG) stimulation. Before and after this value and the relationship between gastric juice acidity and pepsin activity, the clinical intention of measuring the CEA value of gastric juice was collected.