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目的 :对氟尿嘧啶不同给药方法的效果加以对比 ,以了解氟尿嘧啶明胶微球在体内的释药特点。方法 :在 X线监控下 ,将氟尿嘧啶明胶微球超选择栓塞在兔颈外动脉及其分支 ,以氟尿嘧啶溶液灌注颈外动脉或在股静脉静滴作为对照 ,不同时间点取血样测试血药浓度 ,进行统计分析。取栓塞组织石蜡切片 ,常规 HE染色 ,光镜观察。结果 :动脉灌注法可以产生局部较高的血药浓度 ,但维持时间较短 ;静脉滴注法血药浓度维持时间较长 ,但局部与全身血药浓度无显著差异 ;使用氟尿嘧啶明胶微球进行栓塞可以在较小的用药剂量上在局部维持相对较长时间的较高的血药浓度。结论 :氟尿嘧啶明胶微球进行动脉栓塞可以显著降低全身血药浓度及用药剂量 ,达到肿瘤靶向治疗的目的。
Objective : To compare the effects of different methods of administration of fluorouracil to understand the release characteristics of fluorouracil gelatin microspheres in vivo. METHODS: Under X-ray monitoring, fluorouracil gelatin microspheres were superselectively embolized in the external carotid artery and its branches. Peripheral carotid artery was perfused with fluorouracil solution or femoral vein infusion was used as a control. Blood samples were taken at different time points to test blood concentration. ,conduct statistical analysis. Embolized tissue paraffin sections, routine HE staining, light microscopy. Results: The arterial perfusion method can produce high local plasma concentrations, but the maintenance time is shorter. The blood concentration of the intravenous drip infusion method is longer, but there is no significant difference between local and systemic plasma concentrations; use of fluorouracil gelatin microspheres Embolization can locally maintain relatively high plasma concentrations for a relatively long period of time. Conclusion : Arterial embolization with fluorouracil gelatin microspheres can significantly reduce the systemic plasma concentration and dose, and achieve the purpose of targeted tumor therapy.