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目的:探讨诱导型一氧化氮合酶(ｉＮＯＳ)在脑胶质瘤的中表达及意义。方法:检测４Ｏ例脑胶质瘤中ｉＮＯＳ蛋白,分析ｉＮＯＳ与胶质瘤恶性程度的相关关系。结果:①对照组无ｉＮＯＳ表达,胶质瘤组ｉＮＯＳ阳性表达率为６２．５%;②低恶性与高恶性度肿瘤ｉＮＯＳ表达不同;③胶质瘤恶性程度与ｉＮＯＳ染色深浅及阳性细胞数百分比之间呈正相关关系。结论:ｉＮＯＳ产生的ＮＯ参与了胶质瘤从低恶性度向高恶性转化的发展过程,对实体脑肿瘤的生长及侵袭有重要作用,是高级别肿瘤区别于低级别肿瘤的一个重要的病理学特点。
Objective: To investigate the expression and significance of inducible nitric oxide synthase (iNOS) in gliomas. Methods: 4O cases of glioma iNOS protein was detected, iNOS and glioma malignancy correlation analysis. Results: ①No iNOS expression in the control group, the iNOS positive expression rate was 62.5% in glioma group; ② The expression of iNOS was different in low-grade and high-grade malignant tumors; ③ The degree of glioma and iNOS staining and the percentage of positive cells A positive correlation between. CONCLUSION: NO produced by iNOS is involved in the development of glioma from low-grade to high-grade, which plays an important role in the growth and invasion of solid brain tumors. It is an important pathological differentiator between high-grade and low-grade tumors Features.