微量~(14)C—尿素呼气试验检测各种胃粘膜病变的Hp感染

• 作 者: 王群燕 徐晶 季峰 厉有名 王杭勇 黄怀德 陈建永
• 机 构: 浙江医科大学附属一院!310003,浙江医科大学附属一院!310003,浙江医科大学附属一院!310003,浙江医科大学附属一院!310003,浙江医科大学附属一院!310003,浙江医科大学附属一院
• 出 处: 浙江医学
• 发表日期: 1999年09期
• 关键词: 尿素呼气试验 Hp感染 胃粘膜病变 肠上皮化生 HP 胃病患者 活动性慢性胃炎 消化性溃疡 有显著性差异 每分钟计数

为探讨幽门螺杆菌(Hp)感染与胃粘膜病变的关系。应用微量~(14)C-尿素呼气试验(UBT)检测272例胃病患者,结果发现消化性溃疡UBT计数(933±152tpm)显著高于慢性胃炎(552±41dpm),轻、中、重度活动性慢性胃炎UBT计数分别为211±13、547±57、784±96dpm.均有显著性差异(均P<0.05):轻、中、重度胃粘膜萎缩及肠上皮化生UBT计数分别为261±54、513±101、807±201dpm及412±67、817±185、1203±367dpm,大多有显著性差异(P<0.05或P<0.01):提示Hp感染与胃粘膜病变有关

To investigate the relationship between Helicobacter pylori (Hp) infection and gastric mucosal lesions. 272 gastric ulcer patients were detected by micro- (14) C-urea breath test (UBT). The results showed that the UBT count of peptic ulcer (933 ± 152tpm) was significantly higher than that of chronic gastritis (552 ± 41dpm) The UBT counts of chronic gastritis were 211 ± 13,547 ± 57,784 ± 96dpm, respectively (all P <0.05). The counts of UBT in mild, moderate and severe gastric mucosal atrophy and intestinal metaplasia were 261 ± 54,513 ± 101,807 ± 201dpm and 412 ± 67,817 ± 185,1203 ± 367dpm, respectively. Most of them had significant difference (P <0.05 or P <0.01), which suggested that Hp infection was associated with gastric mucosal lesions