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抗体芯片作为蛋白质芯片的一种,具有微型化、集成化、高通量化的特点,可以用于检测某一特定的生理或病理过程相关蛋白的表达丰度,目前主要用于信号转导、基础蛋白质组学研究、肿瘤及其他疾病相关分子的发现、诊断和治疗。在慢性肾病的进程中,复杂的细胞因子网络共同参与了肾间质纤维化的发生、发展,用抗体芯片来鉴定肾组织中的异常表达蛋白,进而进行慢性肾病的早期诊断和治疗监测有较大的临床价值。
As a kind of protein chip, antibody chip has the characteristics of miniaturization, integration and high-throughput. It can be used to detect the expression abundance of protein related to a specific physiological or pathological process, and is mainly used for signal transduction, basic protein Group study, cancer and other disease-related molecules found, diagnosis and treatment. In the process of chronic kidney disease, complex cytokine networks are involved in the occurrence and development of renal interstitial fibrosis, with antibody chip to identify abnormal expression of protein in kidney tissue, and then for the early diagnosis and treatment of chronic kidney disease have more Great clinical value.