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目的探讨原发性IgA肾病临床特征与病理间的关系。方法回顾性分析2006年1月2008年6月经肾活检诊断为原发性IgA肾病患者109例的临床病理资料。结果血尿的发生及血尿的程度与肾活检病理Lee分级无关,而尿蛋白定量、症状性高血压、肾功能受损与病理学分级呈正相关,且与肾小球硬化、间质病变等病理特征呈正相关。结论大量蛋白尿、症状性高血压等是IgA肾病预后不良的重要因素,需要积极干预。
Objective To investigate the relationship between clinical features and pathology of primary IgA nephropathy. Methods The clinical and pathological data of 109 cases diagnosed as primary IgA nephropathy by renal biopsy in January 2006 and June 2008 were analyzed retrospectively. Results The incidence of hematuria and the degree of hematuria were not correlated with the pathological grade of renal biopsy, but the proteinuria of urine, symptomatic hypertension and impaired renal function were positively correlated with pathological grade, and were associated with pathological features such as glomerulosclerosis and interstitial lesions Was positively correlated. Conclusions A large number of proteinuria and symptomatic hypertension are important factors in the poor prognosis of IgA nephropathy and require active intervention.