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Cytidine base editors (CBEs,rAPOBEC1-nCas9-UGI) and adenine base editors (ABEs,TadA-TadA*-nCas9) are newly developed genome-editing tools that have enabled highly efficient base conversions (C·G to T·A or A·T to G·C) at designated target sites (Komor et al.,2016;Gaudelli et al.,2017).Both types of base editors enzymatically catalyze deamination of target bases and respectively replace C with U or A with I.