【摘 要】
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Dear Editor,Genetic engineering of T ceils to express chimeric antigen receptors (CARs) is an efficient approach for clinical therapy of hematological malignanc
【机 构】
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State Key Laboratory of Reproductive Biology, Institute of Zoology,Chinese Academy of Sciences, Beij
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Dear Editor,Genetic engineering of T ceils to express chimeric antigen receptors (CARs) is an efficient approach for clinical therapy of hematological malignancies (Kuwana et al.,1987;Eshhar et al.,1993;Barrett et al.,2014).The CARs endow T cells with the ability to recognize specific antigens and bind them in an MHC-independent manner,thereby overcoming some of the mechanisms that mediate tumor immune escape.In addition,by providing co-stimulatory signals,CARs endow T cells with enhanced cytotoxicity and persistence compared with primary T cells.A typical CAR comprises a single-chain variable fragment (scFv) derived from a monoclonal antibody (mAb) for antigen recognition and signaling domains for coactivation (Eshhar et al.,1993;Sadelain et al.,2013).
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