【摘 要】
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Dear Editor,Safeguarding cellular redox homeostasis is crucial for maintaining organism health and preventing diseases.Oxidative stress,often characterized by d
【机 构】
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National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute
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Dear Editor,Safeguarding cellular redox homeostasis is crucial for maintaining organism health and preventing diseases.Oxidative stress,often characterized by decreased mitochondrial integrity and increased reactive oxygen species (ROS) production,disrupts proteostasis and genomic stability,which may eventually lead to cellular decomposition (Oh et al.,2014).Stem cells (such as mesenchymal stem cells,MSCs,and neural stem cells,NSCs) are susceptible to various exteal and intemal stresses,and their dysfunction contributes to aging and aging-related diseases.Thus,it is of importance to elucidate the complex signaling networks regulated by oxidative stress in stem cells.Although redox signaling has been implicated in multiple cellular processes,how the redox system functions in various human stem cells is unclear.
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