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鼻咽癌95％以上属于低分化鳞癌,对放射治疗敏感度高,疗效颇佳,已列为经典治疗方法。然而即使应用现有高能放射机器,如~(60)Co或直线加速器,病人放疗后的5年生存率亦仅50％或可增至70％。还有1/3或半数病人经放射治疗后仍要求在复发或转移后使用化学治疗。特别因为放射治疗是局部治疗手段,而鼻咽癌的远处转移率颇高,往往成为治疗失败的原因,将化疗与放疗综合应用将是重要的研究课题。鼻咽癌有“广东瘤”之称,多见于华南地区,在广东省珠江三角洲和西江流域各县市为高发。中山医科大学附属肿瘤医院1964～1982年间共诊治恶性肿瘤159396例,其中鼻
More than 95% of nasopharyngeal cancers are poorly differentiated squamous cell carcinomas. They are highly sensitive to radiation therapy and have good curative effects. They have been classified as classic treatment methods. However, even with the use of existing high-energy radiation machines, such as ~(60)Co or linear accelerators, the 5-year survival rate after patient radiotherapy is only 50% or can be increased to 70%. One-third or half of patients still require chemotherapy after recurrence or metastasis after radiation therapy. Especially because radiotherapy is a local treatment method, and the distant metastasis rate of nasopharyngeal carcinoma is high, it is often the cause of treatment failure. Comprehensive application of chemotherapy and radiotherapy will be an important research topic. Nasopharyngeal carcinoma is known as “Guangdong Tumor,” and is more common in southern China. It has high prevalence in the Pearl River Delta of Guangdong Province and counties and cities in the Xijiang River Basin. A total of 159,396 malignant tumors were diagnosed and treated by the Cancer Hospital of Sun Yat-sen University of Medical Sciences from 1964 to 1982.