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本研究采用现代时间生物学的研究方法，探索肝癌临床易感性的年生物周期差异，特别是找到肝癌早期普查的最佳期，以提高肝癌早期发现水平。一、方法及选点采样现代时间生物学研究数据处理的主要方法是余弦法（Cosinor），它是通过一条余弦曲线，用最小二乘方来拟合一组周期数据
This study uses modern time biology research methods to explore the differences in the annual biological cycle of clinical susceptibility to liver cancer, and in particular to find the best period for early screening of liver cancer in order to improve early detection of liver cancer. First, Methods and Setpoint Sampling The main method of data processing in modern time biology research is the cosine method, which uses a cosine curve to fit a set of periodic data using least squares.