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目的分析脑出血急性期患者血浆去甲肾上腺素(NE)、乙酰胆碱(Ach)的变化及临床意义。方法选择45例初发脑出血患者(观察组)和38例健康体检者(对照组),记录观察组入院第2、10天的平均动脉压、心率、呼吸及血糖水平,入院时及住院第10天完善头颅CT检查,并计算颅内血肿体积;入院第2、10天测定两组血浆NE及Ach水平。结果观察组入院时及入院第10天颅内血肿体积分别为(29.70±4.90)、(22.00±5.05)m L,入院后第2天和第10天平均动脉压、心率、呼吸及血糖水平比较无统计学差异(P均>0.05)。观察组第2天、第10天血浆NE水平明显高于对照组(P均<0.01);血浆乙酰胆碱水平明显低于对照组(P均<0.01);观察组血浆NE、Ach水平第2天与第10天比较无统计学差异(P均>0.05)。结论脑出血急性期患者血浆NE水平明显升高、Ach水平明显降低,可能与患者的临床症状有一定联系。
Objective To analyze the changes of plasma norepinephrine (NE) and acetylcholine (Ach) in patients with acute cerebral hemorrhage and its clinical significance. Methods 45 cases of newly diagnosed intracerebral hemorrhage (observation group) and 38 healthy subjects (control group) were enrolled in this study. Mean arterial pressure, heart rate, respiration and blood glucose level were recorded on the 2nd and 10th days after admission in the observation group. 10 days perfect cranial CT examination, and calculate the volume of intracranial hematoma; 2, 10 days after admission were measured plasma NE and Ach levels. Results The volume of intracranial hematoma in the observation group was (29.70 ± 4.90) and (22.00 ± 5.05) m L on admission and on the 10th day after admission, respectively. The mean arterial pressure, heart rate, respiration and blood glucose levels on the 2nd and 10th days after admission No statistical difference (P> 0.05). The levels of plasma NE and Ach in the observation group were significantly higher than those in the control group on the 2nd day and the 10th day (all P <0.01), while the levels of plasma ACh were significantly lower than those in the control group (all P <0.01) There was no significant difference on the 10th day (all P> 0.05). Conclusion The levels of NE in plasma and Ach in patients with acute cerebral hemorrhage are significantly lower than those in patients with acute cerebral hemorrhage, which may be related to the clinical symptoms of patients.