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目的:探讨结节病患者支气管肺泡灌洗液中中性粒细胞、淋巴细胞及T淋巴细胞亚群CD4+T淋巴细胞、CD8+T淋巴细胞、CD4/CD8比值与CT影像之间的相关性。方法:行纤维支气管镜下支气管肺泡灌洗及肺CT检查的结节病患者59例,按照CT表现分为无肺内病变组(23例),有肺内病变组(36例),比较2组患者支气管肺泡灌洗液中中性粒细胞、淋巴细胞、CD4+T淋巴细胞、CD8+T淋巴细胞及CD4/CD8比值的水平。结果:有肺内病变组较无肺内病变组支气管肺泡灌洗液中中性粒细胞升高(P<0.05),CD8+T淋巴细胞增高(P<0.05),CD4/CD8比值下降(P<0.05),淋巴细胞和CD4+T淋巴细胞差异无统计学意义(P>0.05)。结论:结节病患者可根据肺CT影像评估支气管肺泡灌洗液中各种淋巴细胞亚型变化的趋势。
OBJECTIVE: To investigate the correlation between CD4 + T lymphocyte, CD8 + T lymphocyte, CD4 / CD8 ratio and CT image of bronchial alveolar lavage fluid in patients with sarcoidosis in neutrophil, lymphocyte and T lymphocyte subsets . Methods: Fifty-nine patients with sarcoidosis under bronchofibroscopy and bronchial alveolar lavage were divided into two groups according to their CT findings: 23 cases without pulmonary lesions and 36 cases with lung lesions. The level of neutrophil, lymphocyte, CD4 + T lymphocyte, CD8 + T lymphocyte and CD4 / CD8 in bronchoalveolar lavage fluid of patients in group B were higher than those in control group. Results: Compared with the group without pulmonary lesions, the number of neutrophils in bronchoalveolar lavage fluid (P <0.05) and CD8 + T lymphocytes increased (P <0.05) and the ratio of CD4 / CD8 decreased <0.05). There was no significant difference between lymphocytes and CD4 + T lymphocytes (P> 0.05). CONCLUSIONS: Patients with sarcoidosis can evaluate the changes of various lymphocyte subtypes in bronchoalveolar lavage fluid based on CT images of lung.