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目的为临床正确应用糖代谢药物提供参考依据。方法根据相关文献结合临床实际进行归纳和总结。结果氟喹诺酮类药物加替沙星可能是通过阻断胰岛β细胞中的ATP敏感的钾通道,促进胰岛素释放,引发低血糖;阿司匹林引起低血糖的可能机制是药物导致胰岛素代谢清除下降,肝糖生成减少,外周组织对葡萄糖的利用增加;某些心血管药物引起低血糖的可能机制是药物增加胰岛素敏感性,导致外周葡萄糖摄取增加以及抑制脂肪分解等。结论药源性低血糖症常发生于糖尿病患者的常规治疗中,但在少数情况下,无论是糖尿病或非糖尿病患者,其他类药物也可引起低血糖的发生。临床在应用影响糖代谢的药物时,及时监测血糖则可避免或减少药源性低血糖的发生。
Objective To provide a reference for the clinical application of glucose metabolism drugs. Methods According to the relevant literature combined with clinical practice to summarize and summarize. Results Fluoroquinolones gatifloxacin may promote insulin release and block hypoglycemia by blocking ATP-sensitive potassium channels in pancreatic β-cells. The possible mechanism of aspirin-induced hypoglycemia is that the drug leads to the decrease of insulin metabolism clearance, Reduce the production of peripheral tissue to increase the use of glucose; some cardiovascular drugs may cause hypoglycemia mechanism is that drugs increase insulin sensitivity, leading to increased peripheral glucose uptake and inhibition of lipolysis and so on. Conclusion Drug-induced hypoglycemia often occurs in the routine treatment of diabetic patients, but in a few cases, whether it is diabetic or non-diabetic patients, other drugs can also cause hypoglycemia. Clinical application of drugs that affect glucose metabolism, timely monitoring of blood glucose can avoid or reduce the incidence of drug-induced hypoglycemia.