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目的:探讨败血症患儿血浆降钙素原(PCT)和白细胞介素-6(IL-6)的变化及其临床意义。方法:应用双抗夹心免疫法(ILMA)测定血浆PCT水平,酶联免疫(ELISA)双抗体夹心法测定血浆IL-6水平。结果:新生儿败血症组血浆PCT和IL-6急性期水平分别为15.6±7.2μg/L和254.9±53.5 ng/L,恢复期二项指标分别为1.1±0.4μg/L和70.3±15.2 ng/L,对照组二项指标分别为0.9±0.3μg/L和65.0±13.7 ng/L,新生儿败血症组PCT和IL-6水平急性期明显高于恢复期,急性期明显高于对照组(P<0.01)。结论:血浆PCT和IL-6可作为新生儿败血症快速有效诊断参考指标和评估病情的检测指标。
Objective: To investigate the changes of plasma procalcitonin (PCT) and interleukin-6 (IL-6) in children with sepsis and its clinical significance. Methods: Plasma PCT levels were measured by double-antibody sandwich immunoassay (ILMA) and plasma IL-6 levels by enzyme-linked immunosorbent assay (ELISA). Results: The plasma levels of PCT and IL-6 in neonatal sepsis group were 15.6 ± 7.2μg / L and 254.9 ± 53.5ng / L respectively, and the recovery indexes were 1.1 ± 0.4μg / L and 70.3 ± 15.2ng / L, the control group of two indicators were 0.9 ± 0.3μg / L and 65.0 ± 13.7 ng / L, neonatal sepsis group of PCT and IL-6 levels were significantly higher than the recovery period acute phase was significantly higher than the control group (P <0.01). Conclusion: Plasma PCT and IL-6 can be used as a fast and effective diagnostic reference index for neonatal sepsis and as a detection indicator of the disease.