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许多研究资料表明,脑内单胺类介质与癫痫的发病和抗癫痫药物的作用有密切的关系。我们初步研究了7903抗小鼠电惊厥作用与脑内单胺类介质的关系。给小鼠皮下注射利血平(1毫克/公斤)耗竭脑内单胺类介质后可以明显减弱7903的抗电惊厥效应,
Many studies have shown that the brain monoaminergic medium and the incidence of epilepsy and antiepileptic drugs are closely related. We preliminary study 7903 anticonvulsant effect and brain monoamine mediator. Subcutaneous injection of reserpine (1 mg / kg) to mice after brain monoaminergic depletion significantly attenuated the anti-convulsant effect of 7903,