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目的:探究来曲唑对多囊卵巢综合征(PCOS)不孕症患者机体内分泌功能及妊娠率的影响。方法:选取2014年3月—2016年5月间收治的PCOS不孕症患者88例,采用随机分组法将其分为对照组44例和治疗组44例;对照组患者给予人绝经期促性腺激素(HMG),治疗组患者在对照组基础上加用来曲唑治疗,比较两组患者治疗后促卵泡素(FSH)、促黄体生成素(LH)、睾酮(T)、促黄体生成素-促卵泡水平(LH-FSH)的变化情况,随访6月后妊娠率。结果:治疗后治疗组患者LH、T、LH-FSH均低于对照组(P<0.05);6月后随访,治疗组患者妊娠率为56.81%高于对照组为34.09%(χ2=4.583,P<0.05)。结论:采用来曲唑明显改善PCOS不孕症患者机体内分泌功能,提高了妊娠率。
Objective: To investigate the impact of letrozole on endocrine function and pregnancy rate in women with polycystic ovary syndrome (PCOS) infertility. Methods: From March 2014 to May 2016, 88 patients with PCOS infertility were selected and randomly divided into control group (44 cases) and treatment group (44 cases). Patients in the control group were given menopause gonadotropin (HMG). Patients in the treatment group were treated with letrozole on the basis of the control group. FSH, LH, T and LH were compared between the two groups Follicle level (LH-FSH) changes, follow-up after 6 months of pregnancy rate. Results: After treatment, the LH, T and LH-FSH levels in the treatment group were significantly lower than those in the control group (P <0.05). After 6 months of follow-up, the pregnancy rate was 56.81% in the treatment group and 34.09% in the control group (χ2 = 4.583, P <0.05). Conclusion: Letrozole significantly improves the endocrine function and improves the pregnancy rate in patients with PCOS infertility.