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肿瘤细胞具有逃避免疫系统识别和攻击的能力,这种能力是在肿瘤细胞与免疫系统相互作用的过程中形成的。Schreiber和Dunn等2002年首次提出肿瘤免疫编辑学说,包括免疫清除、免疫平衡和免疫逃逸三个阶段。HLA-G属于非经典HLA I类分子,因其在肿瘤细胞的异位表达及其能对宿主抗肿瘤免疫产生广泛抑制作用,参与肿瘤免疫编辑的各个阶段而受到关注。本文就HLA-G的基因和分子结构、HLA-G产生免疫抑制作用的可能机制及HLA-G在肿瘤细胞免疫编辑过程中的作用作一综述。
Tumor cells have the ability to evade recognition and attack by the immune system, which is formed during the interaction of tumor cells with the immune system. Schreiber and Dunn et al first proposed the theory of tumor immunity editing in 2002, including three stages: immune clearance, immune balance and immune escape. HLA-G is a non-classical HLA class I molecule, attracting attention in all stages of tumor immune editing because of its ectopic expression in tumor cells and its broad inhibitory effect on host anti-tumor immunity. In this review, we review the gene and molecular structure of HLA-G, the possible mechanism of HLA-G immunosuppression and the role of HLA-G in tumor cell immune editing.