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慢性血吸虫病对机体造成的病理损害以血吸虫病肝纤维化最为突出,然而目前对血吸虫病造成肝纤维化的发病机制仍缺乏足够的认识,也缺乏有效的抗肝纤维化药物。本文主要阐述了Hedgehog信号通路参与血吸虫病肝纤维化发病机制的最新研究进展,并探讨了相应的药物干预手段。Hedgehog信号通路抑制剂可能会是血吸虫病肝纤维化患者的福音。
Chronic schistosomiasis caused by pathological damage to schistosomiasis liver fibrosis most prominent, but the pathogenesis of schistosomiasis caused by liver fibrosis is still lack of adequate understanding of the lack of effective anti-liver fibrosis drugs. This article mainly expounds the latest research progress on the involvement of Hedgehog signaling pathway in the pathogenesis of hepatic fibrosis in schistosomiasis and discusses the corresponding means of drug intervention. Hedgehog signaling pathway inhibitors may be a boon to schistosomiasis patients with liver fibrosis.