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目的:探讨阿托伐他汀的强化降脂及安全性。方法:临床药师通过对一名老年脑卒中患者应用阿托伐他汀后出现肝毒性等不良反应进行药学服务,并对阿托伐他汀强化降脂、稳定斑块和安全性等相关问题进行探讨。结果:阿托伐他汀对脑卒中的一、二级预防具有积极意义,但作为临床药师和医生应注意其不良反应。结论:阿托伐他汀强化降脂安全有效,耐受性良好,不良反应较轻微,但在实际应用中剂量不宜过大,可从较低剂量开始。
Objective: To investigate the enhancement of lipid lowering and safety of atorvastatin. METHODS: Clinical pharmacists conducted pharmacy services through adverse reactions such as hepatotoxicity after atorvastatin treatment in elderly stroke patients, and discussed the related problems such as lipid lowering, stable plaque and safety of atorvastatin. Results: Atorvastatin has a positive effect on primary and secondary prevention of stroke, but its clinical pharmacists and doctors should pay attention to its adverse reactions. Conclusion: Atorvastatin is safe and effective in reducing lipid lowering. It is well tolerated and has mild adverse reactions. However, in practice, the dosage should not be too large, but it may start from a lower dosage.