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目的:通过线栓法造成大鼠局灶性脑梗死,观察寒性药物豨莶草提取物对大鼠脑梗死的保护作用。方法:将大鼠分为4组,分别为模型组,阳性药物尼莫地平12mg/kg组,假手术组,豨莶草提取物7g生药/kg给药组。灌胃给药,观察药物对大鼠大脑中动脉阻断模型脑梗死面积、行为学指标、血清SOD,MDA含量等指标变化的影响。结果:豨莶草提取物可减小模型动物梗死面积,对行为学指标有一定的降低趋势、血清SOD,MDA含量等指标有一定的影响,但不具有统计学差异。结论:豨莶草提取物对大鼠脑梗死可能具有一定的保护作用。
OBJECTIVE: To observe the protective effect of the extract of Achyranthes grass of cold drug on cerebral infarction in rats by focal cerebral infarction. Methods: The rats were divided into 4 groups: model group, nimodipine 12 mg / kg group, sham operation group and Achnatherum splendens extract 7 g crude drug / kg group. The rats were administered intragastrically to observe the influence of the drugs on cerebral infarction area, behavioral indexes, serum SOD, MDA content in middle cerebral artery occlusion rats. Results: The extract of Achnatherum splendens could reduce the area of infarction in model animals, reduce the behavioral indexes, and have certain influence on the indexes of serum SOD and MDA, but there is no statistical difference. Conclusion: Achnatherum splendens extract may have a protective effect on cerebral infarction in rats.