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目的:探讨苍耳子对SD大鼠鼻内径路给药的急性毒性。方法:按《中药、天然药物急性毒性试验技术指导原则》,观察苍耳子水煎剂经鼻内径路给药后大鼠的急性毒性反应。包括动物给药后饲养期间的大体情况、动物大体解剖情况以及对出现异常器官行组织病理学检查等。结果:A、B组一般情况观察、标本病理学观察均未见异常;C组出现鼻腔分泌物增多、呼吸稍促,给药后4h症状消失,标本病理学观察未见异常。结论:苍耳子鼻内径路给药急性毒性方面是可行且安全的。
Objective: To investigate the acute toxicity of Xanthium siblings on the intranasal route of SD rats. Methods: According to the “Guiding Principles of Acute Toxicity Test of Traditional Chinese Medicine and Natural Medicine”, the acute toxicity of Xanthium sibirici decoction to rats after intranasal route administration was observed. Including animal feeding after the general situation, the general anatomy of animals and the occurrence of abnormal organ histopathological examination. Results: There were no abnormalities in the observation of pathological observation in group A and group B, nasal secretions increased in group C, respiration was slightly delayed, symptoms disappeared 4h after administration, and no abnormalities were observed in the pathological specimens. Conclusion: Xanthium nasal route is feasible and safe for acute toxicity.