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目的:了解不孕不育患者的生殖道支原体感染状况,并探讨生殖道支原体对抗菌药物的耐药性。方法:于2013年1月至2016年4月,选取该阶段内封开县计划生育服务站收治的200例不孕不育患者和200例已生育的健康夫妇,分别设置为观察组、对照组。采集受检者的生殖道分泌物作为检测样本,采用支原体鉴定试剂盒对样本进行检测,统计两组受检者的生殖道支原体感染情况。采用支原体药敏试剂盒对筛选出的支原体菌株进行药敏试验,分析生殖道支原体感染对不同抗菌药物的敏感性。结果:观察组的生殖道支原体感染率为49%,与对照组的24%相比,差异具有统计学意义(P<0.05)。生殖道支原体对交沙霉素、美满霉素、强力霉素、四环素、阿奇霉素的药物敏感性较高,分别为93.51%、92.21%、91.56%、82.47%、80.52%,生殖道支原体对诺氟沙星、环丙沙星的耐药性较高,高达94.52%、95.21%。结论:不孕不育患者的生殖道支原体感染患病率相对于健康育龄人群更高,生殖道支原体对部分抗菌药物的耐药性较高,临床治疗前应根据生殖道支原体感染患者的药敏试验结果合理选择药物,可将交沙霉素、美满霉素、强力霉素作为首选药物。
Objective: To understand the genital mycoplasma infection in infertile patients, and to explore the antibiotic resistance of Mycoplasma genitalium. Methods: From January 2013 to April 2016, 200 infertile infertile women and 200 healthy couples were enrolled in the family planning service station of Fengkai County in this period, and were respectively set as observation group and control group. The subjects’ reproductive tract secretions were collected as the test sample, and the mycoplasma identification kit was used to test the samples. Mycoplasma infection of the two groups were statistically analyzed. Mycoplasma drug susceptibility test kit was used to screen mycoplasma strains for susceptibility testing. The sensitivity of mycoplasma infection to different antimicrobial agents was analyzed. Results: Mycoplasma infection rate in observation group was 49%, which was significantly different from that in control group (P <0.05). Mycoplasma genital tract of josamycin, minocycline, doxycycline, tetracycline, azithromycin drug sensitivity, respectively, 93.51%, 92.21%, 91.56%, 82.47%, 80.52%, Mycoplasma genitalium norfloxacin The drug resistance of cinnabar and ciprofloxacin was higher, reaching 94.52% and 95.21%. Conclusion: The prevalence of mycoplasma genitalium infection in infertile patients is higher than that of healthy reproductive age population. Mycoplasma genitalium is more resistant to some antimicrobial agents. According to the drug susceptibility of patients with genital mycoplasma infection before clinical treatment Test results reasonable choice of drugs, josamycin, minocycline, doxycycline as the drug of choice.