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早在1878年Langley在研究阿托品和匹罗卡品对唾液分泌的拮抗作用时,提出药物必须与机体组织的一些部分结合,才能发生药理作用,他把这一部位称为“接受物质”(Receptive substance),这是最早的受体概念。受体学说经过一百多年来,特别是近十年来的研究和探讨,已经不是理论性的假说,而是通过不少实验证实,存在于细胞膜和细胞内接受化学物质作用的实体。现在,受体学说不仅是药理学的基本理论,而且是
As early as 1878 when Langley was studying the antagonism of saliva secretion by atropine and pilocarpine, it was suggested that the drug must bind to some parts of the body tissue for pharmacological effects. He referred to this part as “Receptive” substance, which is the earliest receptor concept. Reciprocal theory After more than one hundred years, especially in the past ten years of research and discussion, is not a theoretical hypothesis, but through a lot of experiments confirmed that exist in the plasma membrane and cells to accept the role of chemical entities. Now, the receptor theory is not only the basic theory of pharmacology, but also