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实验显示戊二醛塑化剂（ＧＲ）具有与甲塑化剂（ＦＲ）相同的塑化作用和抑菌作用，在封闭条件下没有体积改变，溶于水中的程度也相似。表明ＧＲ可替代ＦＲ作为塑化治疗用药，以避免甲醛的致畸变、致癌变等毒性对患者造成的损害。ＧＲ的固化速度慢于ＦＲ，但可通过增加催化剂──氢氧化钠来调节。未塑化的ＧＲ对组织造成的损害主要为组织坏死，而ＦＲ主要为组织变性，前者的修复慢于后者，因此在临床应用中要特别注意避免ＧＲ渗出到根尖孔外。
Experiments show that glutaraldehyde plasticizer (GR) has the same plasticizing agent and bacteriostatic effect as methyl plasticizer (FR), with no change in volume under closed condition and similar degree of dissolution in water. It is indicated that GR can replace FR as a plasticizing agent to avoid damage to patients caused by toxicity such as teratogenicity and carcinogenicity of formaldehyde. GR cures slower than FR, but can be adjusted by adding a catalyst, sodium hydroxide. Unplasticized GR damage to the tissue is mainly caused by tissue necrosis, and FR is mainly for tissue degeneration, the former is slower than the latter repair, so in clinical applications should pay special attention to prevent GR exudation to the apical foramen.