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由我国卫生部和世界卫生组织在去年12月联合召开的男性生育调节学术交流会上,来自十二个国家的科学家高度评价了我国在棉酚研究方面所取得的进展。棉酚是一种存在于棉籽中的酚类物质。早在三十年代,山东、江苏农村便有服用棉籽油造成十年不育的事例。1972年前后,我国科学家证实,棉酚能够抑制小白鼠精子的生成。随后全国不少省市进行临床试用共计八千余例,均获得良好的节育效果。本文所列的例数亦包括在内,但服用棉酚控制生育,尚存两个问题亟待解决:一是服用棉酚后,约有百分之一的人出现低血钾;二是长期或短期服用棉酚而剂量偏大者有可能引起曲细精管上皮细胞永久性的退化,甚至有绝育的可能。因此,国外如澳大利亚和西欧一些计划生育研究机构,针对上述两个问题正在加紧深入研究。
At the Symposium on Male Fertility Regulation jointly held by China’s Ministry of Health and World Health Organization in December last year, scientists from 12 countries spoke highly of China’s progress in gossypol research. Gossypol is a phenolic substance present in cottonseed. As early as the thirties, Shandong, Jiangsu Province, there are cases of cottonseed oil consumption caused by ten years of infertility cases. Around 1972, our scientists confirmed that gossypol can inhibit the formation of sperm in mice. Subsequently, many provinces and cities nationwide conducted more than 8,000 clinical trials, all of which achieved good results in contraception. The cases listed in this article are also included, but gossypol control fertility, there are two remaining problems to be solved: First, after taking gossypol, about one percent of people hypokalemia; the second is long-term or Short-term use of gossypol and the larger dose may cause permanent degeneration of seminiferous tubules epithelial cells, and may even sterilization. Therefore, some foreign countries such as Australia and western Europe’s family planning research institutes are stepping up their studies on these two issues.