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目的 观察肾病综合征 (NS)患儿发作期、缓解期与正常小儿及成人肾衰患者尿中 8种蛋白成分变化。方法 对正常儿童、NS缓解期、NS发作期、成人肾衰竭共 4组 6 4例尿液用Sebia电泳分析仪测出 8种蛋白条带百分比。结果 正常儿童及NS缓解组尿中仅有少量清蛋白 ,发作期组尿中以清蛋白、IgG及转铁蛋白为主 ,而肾衰组尿中均有 7～ 8种蛋白出现。 4组患者 7种尿蛋白间比较均有显著性差异。结论 NS患儿发作期尿中以大量中分子蛋白尿为主 ,而NS缓解期尿蛋白消失 ,可能是多数NS预后较好的重要因素。肾衰患者人尿中存在各种类型蛋白。蛋白尿是肾脏病变的标志 ,而蛋白尿有可能是肾恶化的重要因素。
Objective To investigate the changes of eight proteins in urine of patients with nephrotic syndrome (NS) during the onset, remission and normal children and adults with renal failure. Methods A total of 64 urinary samples from 4 children with normal children, NS remission, NS attack and adult renal failure were detected by Sebia electrophoresis analyzer. Results There was only a small amount of albumin in the urine of normal children and NS remission group. Serum albumin, IgG and transferrin were the main urinary excretion in the attacking group, while 7 ~ 8 proteins in the urine of the renal failure group. There were significant differences among the 7 urinary proteins in 4 groups. Conclusion The majority of urinary excretion of proteinuria in NS patients and the disappearance of urinary protein in NS remission may play an important role in the prognosis of NS. There are various types of proteins in human urine in patients with renal failure. Proteinuria is a sign of kidney disease, and proteinuria may be an important factor in the deterioration of the kidneys.