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目的 :探讨宫颈癌中p2 7蛋白的表达及其临床意义。方法 :用免疫组化链霉亲合素 -过氧化物酶染色法 (SP法 ) ,检测 2 2例正常宫颈组织和 4 8例宫颈鳞癌组织中p2 7蛋白的表达。结果 :宫颈癌组织中p2 7蛋白表达的阳性率为 39.5 % ,而正常宫颈组织中的表达率为 72 .7% ,两者差异显著 (P <0 .0 1)。另外 ,p2 7蛋白在宫颈癌组织中表达的阳性率 ,与癌细胞的分化程度、患者的临床分期以及有无淋巴结转移有关。癌细胞分化程度低、晚期患者及有淋巴结转移者 ,p2 7蛋白表达的阳性率低 ,反之则高。结论 :p2 7蛋白表达的阳性率与宫颈癌的分化程度、临床分期及有无淋巴转移有关。检测p2 7蛋白的表达可作为判定宫颈癌病情的参考指标
Objective: To investigate the expression of p27 protein in cervical cancer and its clinical significance. Methods: Immunohistochemical streptavidin - peroxidase staining (SP method) was used to detect the expression of p27 protein in 22 cases of normal cervical tissue and 48 cases of cervical squamous cell carcinoma. Results: The positive rate of p27 protein expression in cervical cancer was 39.5%, while that in normal cervical tissue was 72.7%. There was significant difference between the two groups (P <0.01). In addition, the positive rate of p27 expression in cervical cancer is related to the differentiation of cancer cells, the clinical stage of patients and the presence or absence of lymph node metastasis. Low degree of cancer cell differentiation, advanced patients and patients with lymph node metastasis, p27 protein expression of the positive rate is low, and vice versa. Conclusion: The positive rate of p27 protein expression is related to the differentiation, clinical stage and lymphatic metastasis of cervical cancer. Detection of p27 protein expression can be used as a reference to determine the status of cervical cancer