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目的探讨早期营养支持对肌萎缩侧索硬化患者的临床效果并进行评价。方法方法采用随机数字表法,将2008年8月—2015年1月入院的40例出现明显吞咽困难的肌萎缩侧索硬化患者按入院先后顺序随机分为对照组和营养支持组,每组20例,观察营养支持前后患者白蛋白、血红蛋白营养指标变化情况及并发症发生情况,计量资料以±s表示,采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果营养支持1个月后,营养支持组患者的白蛋白为(39.2±3.99)g/L、血红蛋白为(136.18±16.95)g/L,较营养支持前[(30.1±2.50)、(110.06±14.86)g/L]明显升高,差异均有统计学意义(均P<0.05)。营养支持组患者感染性并发症及非感染性并发症的发生率(50%)低于对照组(25%)。结论肌萎缩侧索硬化患者出现吞咽困难后进行早期营养支持,可以有效改善患者的营养状况,预防和减少并发症的发生。
Objective To investigate the clinical effect of early nutritional support on patients with amyotrophic lateral sclerosis. Methods A random number table method was used to divide 40 patients with amyotrophic lateral sclerosis who had obvious dysphagia admitted from August 2008 to January 2015. The patients were randomly divided into control group and nutrition support group Cases, observation of nutritional support before and after patients with albumin, hemoglobin changes in nutritional status and complications, measurement data to ± s, using t test, count data using χ2 test, P <0.05 was considered statistically significant. Results After 1 month of nutritional support, the patients in nutritional support group had albumin (39.2 ± 3.99) g / L and hemoglobin (136.18 ± 16.95) g / L, which were significantly higher than those before nutritional support [(30.1 ± 2.50) and (110.06 ± 14.86) g / L] were significantly increased, the differences were statistically significant (P <0.05). The incidence of infectious complications and non-infectious complications was lower in the nutrition support group (50%) than in the control group (25%). Conclusion Amyotrophic lateral sclerosis patients with dysphagia after early nutritional support, can effectively improve the nutritional status of patients to prevent and reduce the incidence of complications.