论文部分内容阅读
干扰素-α对减轻慢性丙型肝炎肝细胞损伤和炎症程度有效。不幸的是干扰素并非都有效,疲劳、抑郁、骨髓抑制以及自体免疫性甲状腺病等副作用往往限制了它的应用。三氮唑核苷是一核苷类似物,对RNA病毒包括HCV有广谱抗病毒活性。本文报道了三氮唑核苷治疗13例慢性丙型肝炎感染者达6个月的初步研究结果。病人与方法:受试者为成年慢性丙型肝炎感染患者、血清抗-HCV阳性或肠道外接触虹液或血制品者。入选前血清转氨酶持续升高至少6个月,两次血清ALT检查(相隔至少1个月)值是正常上限的两倍以上。肝活检后,口服三氮唑核苷每日二次,6个月为一疗程。冶疗开始600mg/d,2个月后剂量增至1000mg/d,4个
Interferon-alpha is effective in reducing hepatocellular injury and inflammation in chronic hepatitis C. Unfortunately, interferons are not always effective. Side effects such as fatigue, depression, myelosuppression and autoimmune thyroid disease often limit their utility. Ribavirin is a nucleoside analog that has a broad spectrum of antiviral activity against RNA viruses, including HCV. This paper reports the preliminary results of ribavirin treatment of 13 chronic hepatitis C patients for 6 months. Patients and Methods: Subjects were adults with chronic hepatitis C infection, serum anti-HCV positive or parenteral contact with iris or blood products. Pre-selected serum aminotransferases continued to rise for at least 6 months, and the two serum ALT tests (at least one month apart) were more than twice the upper limit of normal. Liver biopsy, oral ribavirin twice daily, 6 months for a course of treatment. Treatment started 600mg / d, 2 months after the dose increased to 1000mg / d, 4