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目的分析阿奇霉素在鼻内镜术后康复治疗中的应用效果。方法将该院2016年5月—2017年5月接收并行鼻内镜手术治疗的100例患者分作甲组与乙组,每组50例。甲组术后康复治疗期间不适用阿奇霉素,而乙组则在术后7 d接收阿奇霉素治疗,比较两组的康复效果。结果 (1)术后1个月,乙组患者的C-反应蛋白、TNF-α、ICAM-1、IL-1、IL-8的水平均显著优于甲组,差异有统计学意义(P<0.05);(2)乙组患者术后清洗鼻腔、鼻腔完全上皮化、水肿消退等时间均显著短于甲组,差异有统计学意义(P<0.05)。(3)甲组临床治疗有效率是82.0%,低于乙组的96.0%,差异有统计学意义(P<0.05)。结论在鼻内镜手术患者术后康复期间采取阿奇霉素进行治疗,能够发挥显著的抗炎效果,促进患者尽快恢复健康。
Objective To analyze the effect of azithromycin in rehabilitation treatment after endoscopic sinus surgery. Methods A total of 100 patients undergoing concurrent endoscopic sinus surgery from May 2016 to May 2017 in our hospital were divided into group A and group B, with 50 cases in each group. Azithromycin was not suitable for group A during postoperative rehabilitation, while group B received azithromycin 7 days after operation, and the rehabilitation effect was compared between the two groups. Results (1) At 1 month after operation, the levels of C-reactive protein, TNF-α, ICAM-1, IL-1 and IL-8 in group B were significantly better than those in group A (P <0.05). (2) The time of postoperative nasal cleaning, complete epithelialization of nasal cavity and edema disappearance in group B were significantly shorter than that in group A (P <0.05). (3) The effective rate of clinical treatment in group A was 82.0%, which was lower than 96.0% in group B, the difference was statistically significant (P <0.05). Conclusions Azithromycin treatment during postoperative rehabilitation in patients undergoing endoscopic sinus surgery can exert significant anti-inflammatory effects and prompt the patients to resume their health as soon as possible.