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香果脂已收載入新版中国药典,現将它的特点以及收載它的理由略作介紹。栓剂基质的要求主要是在室溫时坚实,在体溫时融化或軟化,无刺激性,与主药不起配伍禁忌,并能迅速释放药物,等等。常用的基质分脂肪性基质与水溶性及亲水性基质。在脂肪性基质中,最常用的是可可豆油(柯柯脂)。由于它在低温时质脆,可以研磨或銼成粉末,与固体药物均匀混和,所以可用冷压法或热熔法制备栓剂,并且在性能上也符合于上述栓剂基质的主要要求,因此各国药典都采用它。但可可豆油也不是沒有缺点的,例如加热熔化的温度不能过高,超过40℃时,它的物理性质就起变化,失去稳定的β型晶核,熔点下降到23—25°,不易凝結,需要放置两周以后,才慢慢恢复原来的β型結晶;又如有些药物如樟脑、水合氯醛、苯酚
Fragrance fat has been included in the new version of the Chinese Pharmacopoeia, now its characteristics and the reasons for its collection slightly introduced. Suppository matrix requirements are mainly solid at room temperature, melted or softened at body temperature, non-irritating, incompatible with the main drug incompatibility, and the rapid release of drugs, and so on. Commonly used matrix sub-fat matrix and water-soluble and hydrophilic matrix. Among fatty matrices, cocoa butter (Keke fat) is the most commonly used. Since it is brittle at low temperatures, it can be ground or filmed into a powder and mixed uniformly with solid medicaments, suppositories can be prepared by cold-pressing or hot-melt methods and also in performance in line with the main requirements of the suppository base described above, Have adopted it. However, cocoa bean oil is not without drawbacks, for example, heating and melting temperature can not be too high, more than 40 ℃, its physical properties change, loss of stable β-type crystal nucleus, melting point down to 23-25 °, not easy to condense, Need to place two weeks later, before slowly recovering the original β-type crystals; Another example is some drugs such as camphor, chloral hydrate, phenol