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目的探讨小儿全身炎症反应综合征(SIRS)早期肾损伤的敏感指标,为早期干预提供理论依据。方法以2000年12月至2001年11月广州市儿童医院儿科病房45例SIRS患儿及30名健康儿童为研究对象,尿β2微球蛋白(β2-MG)、白蛋白(ALB)采用化学发光酶免疫分析法(CLEIA)测定,尿微量IgG、血、尿视黄醇结合蛋白(RBP)采用酶联免疫吸附比色法(ELISA)测定,尿N-α-乙酰基-β-D-氨基葡萄糖苷酶(NAG)采用比色法测定。结果实验组与对照组比较,尿ALB、β2-MG、RBP、NAG、血β2-MG、血RBP明显升高,有显著性差异。结论尿ALB、β2-MG、RBP、NAG、血β2-MG、血RBP为SIRS患儿早期肾损伤的敏感指标,SIRS患儿早期机体反应较轻时已存在早期肾损害并且病变累及肾小球和肾小管。
Objective To investigate the sensitive indexes of early renal injury in children with systemic inflammatory response syndrome (SIRS), and to provide a theoretical basis for early intervention. Methods From December 2000 to November 2001, 45 children with SIRS and 30 healthy children in the pediatric ward of Guangzhou Children’s Hospital were enrolled in this study. Urinary β2-microglobulin (β2-MG) and albumin (ALB) Enzyme Immunoassay (CLEIA), urinary trace IgG, blood and urine retinol binding protein (RBP) were measured by enzyme-linked immunosorbent assay (ELISA), urinary N-α-acetyl-β-D-amino Glucosidase (NAG) was measured by colorimetry. Results Compared with the control group, urinary ALB, β2-MG, RBP, NAG, blood β2-MG and blood RBP were significantly increased in the experimental group and the control group. Conclusions Urinary ALB, β2-MG, RBP, NAG, blood β2-MG and blood RBP are the sensitive indicators of early renal injury in children with SIRS. The early renal damage in early SIRS children has existed early renal damage and the lesions involved glomeruli And tubules.